Name | ifenprodil tartrate |
Synonyms | Dilvax Cerocral Ifenprodil tartrate IFENPRODIL TARTRATE ifenprodil tartrate IFENPRODIL HEMITARTRATE IFENPRODIL TARTRATE SALT 2-(4-BENZYLPIPERIDINO)-1-(4-HYDROXYPHENYL)-1-PROPANOL HEMITARTRATE ALPHA-[4-HYDROXYPHENYL]-BETA-METHYL-4-BENZYL-1-PIPERIDINEETHANOL TARTRATE SALT 4-Benzyl-1-(beta,4-dihydroxy-alpha-methylphenethyl)piperidinium hydrogen tartrate a-(4-Hydroxyphenyl)--methyl-4-(phenylmethyl)-1-piperidineethanol (2R,3R)-2,3-Dihydroxybutanedioate 4-benzyl-1-[1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]piperidinium 3-carboxy-2,3-dihydroxypropanoate |
CAS | 23210-58-4 |
EINECS | 245-493-5 |
InChI | InChI=1/2C21H27NO2.C4H6O6/c2*1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17;5-1(3(7)8)2(6)4(9)10/h2*2-10,16,18,21,23-24H,11-15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1 |
Molecular Formula | C25H33NO8 |
Molar Mass | 475.53 |
Melting Point | 178-180°C |
Boling Point | 956°C at 760 mmHg |
Flash Point | 532°C |
Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
Vapor Presure | 0mmHg at 25°C |
Appearance | White solid |
Color | White |
Storage Condition | Inert atmosphere,2-8°C |
Stability | Hygroscopic |
Use | This product is for scientific research only and shall not be used for other purposes. |
In vitro study | Ifenprodil treatment of oocytes inhibited NMDA-induced currents at NR1A/NR2B and NR1A/NR2A receptors, with IC50 of 0.34 μm and 146 μm respectively and voltage clamp of -70 mV. The extent of inhibition of the NR1A/NR2A receptor by Ifenprodil as a weak open channel blocker of the NR1A/NR2A receptor by 100 μm Ifenprodil was not affected by extracellular glycine concentration. Increasing glycine concentration decreased the inhibitory effect of 1 mM Ifenprodil on the NR1A/NR2B receptor. Ifenprodil (10 μm) acts on young rat cortical neurons and is a single population of high affinity receptors for glycine, inhibiting almost all currents evoked by NMDA receptors. Ifenprodil (10 μm) acted on the cortical neurons of aged rats and inhibited a significant proportion of the high-affinity component and the low-affinity component, revealing three pharmacologically different distribution populations of the NMDA receptor in a single neuron. Ifenprodil antagonizes the NMDA receptor in an activity-dependent manner and also enhances the receptor's affinity for Agonists of glutamate recognition sites. In the inhibition curves of Ifenprodil on 10 μm and 100 μm NMDA induced currents, IC50 was 0.88 μm and 0.17 μm, respectively. Ifenprodil (3 μm) can strengthen the control level of cultured rat cortical neurons. The increase is about 200 percent. The affinity of Ifenprodil for the NMDA receptor in the agonist-bound activated and desensitized states was enhanced 39-and 50-fold compared to the quiescent, agonist-unbound state. Ifenprodil binds to the NMDA receptor with a 6-fold increase in affinity for glutamate receptor agonists. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. |
WGK Germany | 3 |
biological activity | Ifenprodil is an atypical non-competitive NMDA receptor antagonist. in the forebrain of newborn rats, it binds to NMDA receptors with high affinity and IC50 of 0.3 μM. |
Target | Value |
NMDA Receptor | 0.3 μM |